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Open Position:  Senior Scientist

To apply send your curriculum vitae to:

Department:            Research and Development

Location:                  San Diego, CA

Classification:          Exempt




This position reports to the Chief Scientific Officer of the corporation or the CEO if the CSO position is vacant.  The position will be a key member of the research and development teams translating several products from the laboratory to the clinic.  S/he will oversee the design and management of preclinical (GLP and non-GLP) pharmacology and toxicology programs, including animal disease models, pharmacokinetics, and preclinical safety of Trefoil’s IND enabling programs. This includes protocol development, RFP and SOW generation, selection and negotiations with CROs, data analysis and report generation.  The scientist will work as part of the team with research, manufacturing, analytical, and clinical development functions as well as outside advisors, vendors/CROs and consultants. This individual will collaborate with other staff, both inside and outside the company, as well as with CRO staff with whom the company has a contractual arrangement or a working collaboration.  Direct responsibility for management of a laboratory team.



  • Experience with ophthalmic in vivo models, preferably cornea/anterior segment

  • Exhibits a results-oriented approach with a sense of urgency and drive for closure with the ability to execute and prioritize multiple, competing tasks and demands. 

  • Excellent communication skills with the ability to communicate effectively and credibly with all stakeholders

  • Seizes accountability while delegating tasks and responsibilities appropriately

  • Displays a collaborative and team- oriented approach to accomplishing assigned projects.



  • Responsible for managing laboratory staff.  Key focus on mentoring and developing scientific staff.

  • Design, perform and interpret in vivo studies including supervision of junior staff performing same.

  • Identification, qualification, contracting and management of CROs performing animal and bioanalytical work including both GLP and non-GLP studies

  • Preparation of reports and presentations to regulators, board members, advisors, and investigators

  • Organize and execute in vivo pharmacological studies to help characterize biological compounds.

  • Financial oversight on contracts with external consultants and CROs.


  • PhD (or equivalent combination of education and experience) with at least 3 years of further commercial laboratory experience

  • Experience and background in ophthalmology is essential.

  • Prior experience in supervising a team of scientific staff.

  • Experience in a collaborative environment and/or with CROs

  • Experience in GLP laboratory techniques and knowledge of laboratory safety practices. 

  • Experience with histological techniques, including immunohistochemistry and microscopic techniques, as well as other laboratory techniques.

  • Excellent written and verbal communication skills;

  • Creative and demonstrated problem solving and analytical skills;

  • Computer skills: working knowledge of MS-Office (Excel, Word, PowerPoint).

  • Knowledge of graphing and statistical software (e.g., Prism) is a plus.



To perform this job successfully, an individual must be able to carry out each essential duty satisfactorily.  They must be able to travel domestically and internationally.  The requirements listed are representative of the level of knowledge, skill, and/or ability required.  Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.



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